Addition of carbohydrates like mannose to these adjuvants has proved helpful towards building protective immunity against viruses. The Mallapragada group has developed these copolymers as potential vaccine adjuvants candidates. Chapter 3 describes how this strategy was utilized towards the synthesis of a particular alkynyl D-mannose analogue that was then coupled to a class of pentablock copolymers via Huisgen cycloaddition and quantified by various methods. The method does not require low temperatures, or additional additives/co-promoters and tolerates different functional groups including alkenes.Īfter the success of the developed method with alkene-containing compounds, it was applied to the acceptors containing alkynes. A variety of glycosyl donors containing different protecting groups could be coupled to simple and complex glycosyl acceptors in high to excellent yields. Chapter 2 discusses the successes and failures in synthetic trials towards the discovery of this promoter. In lieu of the existing limitations in thioglycoside activation, a simple and efficient methodology was developed for activating thiopropylglycosides utilizing a unique Bi(V) containing promoter. The chapter enlists common methods for their synthesis as well as accounts the available methods for their activation along with advantages/limitations. Chapter 1 is a review on thioglycosides as important glycosyl donors in these processes.
Various worthwhile iterative methods/protocols have been developed and a range of glycosyl donors have been utilized to build oligosaccharides.
To understand their functions better, chemical syntheses of these crucial molecules have been attempted but scientists over the years have found this task to be challenging. Carbohydrates are considered important biomolecules and are the most efficient sources of energy, which is the reason they are known as the "fuel of life." Apart from nutritional functions, they play significant roles in various cell-cell recognition and differentiation, inflammatory responses, pathogen invasion, etc.
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